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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjectswith non-alcoholic fatty liver disease: a translational approach

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: Lingguizhugan Decoction (LGZG) has been investigated in basic studies, with satisfactory effects on insulin resistancein non-alcoholic fatty liver disease (NAFLD).The primary efficacy variable was homeostasis model assessment of insulin resistance (HOMA-IR).Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled    

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Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy

Maliwan NACONSIE,Peng ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 285-294 doi: 10.15302/J-FASE-2016119

Abstract: Also, two viral diseases, cassava mosaic disease (CMD) and cassava brown streak disease (CBSD), causeGenetic engineering provides promising approaches to improve nutritional value and increase resistanceengineering protein content by overexpression of nutritious storage proteins and improving cassava resistance

Keywords： Manihot esculenta     protein enhancement     RNA interference     transgenesis     virus resistance    

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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract:

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simpleInsulin resistance associated with central obesity is the major cause of hepatic steatosis, which is

Keywords： nonalcoholic fatty liver disease     insulin resistance     obesity    

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases currently in theaddition to the classical “Two-hit” theory, NAFLD has been recognized as a typical gut microbiota-related diseasebecause of the intricate role of gut microbiota in maintaining human health and disease formation.

Keywords： gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

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Engineering Disease Resistance in Crop Plants: Callosic Papillae as Potential Targets

Geoffrey B. Fincher

Engineering 2020, Volume 6, Issue 5,   Pages 505-508 doi: 10.1016/j.eng.2020.03.012

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Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAyMoreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-AktXKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

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Synthetic Hexaploid Wheat: Yesterday, Today, and Tomorrow Review

Aili Li,Dengcai Liu,Wuyun Yang,Masahiro Kishii,Long Mao

Engineering 2018, Volume 4, Issue 4,   Pages 552-558 doi: 10.1016/j.eng.2018.07.001

Abstract: It provides new sources for yield potential, drought tolerance, disease resistance, and nutrient-use

Keywords： Synthetic wheat     Wheat     Polyploidization     Disease resistance     Stress tolerance     Yield    

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhfr) and dihydropteroate synthetase (dhps) genes of Plasmodium vivax and antifolate resistance-associatedgenes were used for drug resistance surveillance.This study indicated that the antifolate resistance levels of P. vivax parasites were differentacross China and molecular markers could be used to rapidly monitor drug resistance.

Keywords： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

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Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 1,   Pages 4-4 doi: 10.1007/s11783-021-1438-y

Abstract: Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs).However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system

Keywords： Antibiotic resistance genes     Metal resistance genes     Metagenomic analysis     Microplastics     Mariculture    

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et’s disease in a Chinese population

Shengping Hou, Aize Kijlstra, Peizeng Yang

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 354-359 doi: 10.1007/s11684-012-0234-2

Abstract: et’s disease is defined as a multisystemic inflammatory disease.et’s disease. To explore the genetic factors for Beh?et’s disease, our group investigated the association of Beh?et’s disease with multiple immune response genes and has identified multiple Beh?et’s disease-related immunoregulatory pathways in the Chinese Han population.

Keywords： et’s disease     SNPs     immune gene     genetic study    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract:

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Acupuncture for the management of dry eye disease

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 975-983 doi: 10.1007/s11684-022-0923-4

Abstract: The effectiveness of using acupuncture for dry eye disease (DED) is controversial.outcomes of interests were (1) to evaluate the efficacy of acupuncture in improving the ocular surface disease

Keywords： dry eye disease     xerophthalmus     acupuncture    

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Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development

Long-de Wang

Frontiers of Engineering Management 2015, Volume 2, Issue 1,   Pages 2-12 doi: 10.15302/J-FEM-2015002

Abstract: the status of major chronic diseases in China, analyzing the key issues and key factors in chronic diseasethe previous projects, this paper proposes the following recommendations as strategies for chronic diseaseWork norms and requirements will then improve the performance and efficiency in chronic disease prevention

Keywords： chronic disease prevention and control     strategy and system construction    

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: While most cancer therapies are given in combinations that are designed to avoid drug resistance, wetherapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistanceThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Astrocytes in depression and Alzheimer’s disease

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 829-841 doi: 10.1007/s11684-021-0875-0

Abstract: brain diseases may cause psychosocial and cognitive impairment, such as depression and Alzheimer’s diseasedepression and AD has shown that depression might be a prodrome of progressive degenerative neurological disease

Keywords： astrocytes     depression     Alzheimer’s disease     roles     mechanisms    

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Title Author Date Type Operation

Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjectswith non-alcoholic fatty liver disease: a translational approach

Journal Article

Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy

Maliwan NACONSIE,Peng ZHANG

Journal Article

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

Engineering Disease Resistance in Crop Plants: Callosic Papillae as Potential Targets

Geoffrey B. Fincher

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Synthetic Hexaploid Wheat: Yesterday, Today, and Tomorrow

Aili Li,Dengcai Liu,Wuyun Yang,Masahiro Kishii,Long Mao

Journal Article

Prevalence of antifolate drug resistance markers in in China

Journal Article

Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Journal Article

et’s disease in a Chinese population

Shengping Hou, Aize Kijlstra, Peizeng Yang

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Acupuncture for the management of dry eye disease

Journal Article

Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development

Long-de Wang

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Astrocytes in depression and Alzheimer’s disease

Journal Article